CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia
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چکیده
By Pierre Fenaux, Claude Chastang,† Sylvie Chevret, Miguel Sanz, Hervé Dombret, Eric Archimbaud,† Martin Fey, Consuelo Rayon, Françoise Huguet, Jean-Jacques Sotto, Claude Gardin, Pascale Cony Makhoul, Philippe Travade, Eric Solary, Nathalie Fegueux, Dominique Bordessoule, Jesus San Miguel, Harmut Link, Bernard Desablens, Aspasia Stamatoullas, E. Deconinck, Fréderic Maloisel, Sylvie Castaigne, Claude Preudhomme, and Laurent Degos for the European APL Group
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Treatment of newly diagnosed and relapsed acute promyelocytic leukemia with intravenous liposomal all-trans retinoic acid
A novel intravenous liposomal formulation of all-trans retinoic acid (ATRA) was evaluated in 69 patients with acute promyelocytic leukemia (APL): 32 new diagnoses, 35 relapses, and 2 oral ATRA failures. Liposomal ATRA (90 mg/m2) was administered every other day until complete remission (CR) or a maximum of 56 days. Treatment following CR was liposomal ATRA with or without chemotherapy. In an in...
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Fourteen patients with PML/RARa-positive acute promyelocytic leukemia (APL) were given salvage therapy at the time of first molecular relapse. All patients had achieved first molecular remission after the AIDA protocol (all-trans retinoic acid [ATRA] 1 idarubicin) and were being prospectively monitored by reverse transcriptase-polymerase chain reaction (RT-PCR). Molecular relapse was defined as...
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We compared the efficacy of intensified chemotherapy followed by myeloablative therapy and autologous stem cell rescue with intensified chemotherapy alone in patients newly diagnosed with multiple myeloma. There were 261 eligible patients younger than 66 years with stage II/III multiple myeloma who were randomized after remission induction therapy with vincristine, adriamycin, dexamethasone (VA...
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Despite improvements in the treatment of acute myeloid leukemia (AML), approximately 50% of children die of the disease. Clinical trials in adult patients with AML indicate that idarubicin may have superior efficacy when compared to daunorubicin in the remission-induction phases of chemotherapy. We conducted consecutive clinical trials in children with newly diagnosed AML in which daunorubicin ...
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